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The focus of the Interdisciplinary Science and Engineering Partnership (ISEP) is the critical middle school experiences of students in science and engineering as they transition to high school. The project utilizes an innovative approach to teacher professional development among 12 high-needs urban schools (including "feeder" middle schools and their corresponding high schools) via courses and interdisciplinary research experiences, development of science and technology classroom materials that are aligned with state science learning standards, and inquiry-based curricula. The ISEP also combines novel mentoring approaches and expanded professional learning communities to build leadership and resources for improving science education in high-needs/high-potential urban schools. The learning communities cultivate mentoring relationships involving middle and high school teachers and students, University at Buffalo and Buffalo State College STEM faculty, education faculty, undergraduate students and graduate students, volunteer STEM professionals, and/or parents.